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Finally, though carotid plaque assessment by ultrasound is a surrogate marker, it has now been validated as a meaningful predictor of cardiovascular events, with robust recommendations on the performance, standardization and clinical utility in the prediction of important atherosclerotic outcomes [19]

In patients with loss of function of MECP2 , a possible mechanism for epilepsy is impaired excitatory inhibitory balance onto CA3 pyramidal neurons, leading to a hyperactive hippocampal network (29)

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6,15 In children with frequent attacks (more than 1 or 2 per month), repeated hospitalizations, or poor response to abortive treatment, prophylactic drug treatment may be initiated ( TABLE 2 )

This mechanism controls energy production, detoxification, and emotional balance